Human-health

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• Cancer borealis

  Jonah crab

  Cancer borealis, commonly known as the Jonah crab, is a marine brachyuran crab native to the western Atlantic Ocean. It inhabits waters from Newfoundland to Florida, primarily in rocky marine environments. The species possesses a rounded, rough-edged carapace with small light spots and robust claws with dark brown-black tips. Males reach larger sizes than females, with maximum carapace widths of 222 mm versus approximately 150 mm. The Jonah crab has been extensively studied as a model organism for neurophysiology, particularly for its stomatogastric nervous system, which has contributed to understanding neural circuit function and neuromuscular control.

  model-organismneurophysiologystomatogastric-ganglioncommercial-fisheryrocky-intertidalAtlantic-Oceandecapodcrustaceanion-channel-researchtemperature-adaptationpH-adaptationneural-circuitneuromuscularcompetitionfisheriesmarine-biologycell-identitytranscriptomicspotassium-channelsK2P-channelsmuscle-physiologystomatogastric-nervous-systembiogenic-amine-receptorsGABA-receptorsglutamate-receptorsacetylcholine-receptorsgap-junctionsinnexinsWnt-signalingobesity-researchcolon-cancer-researchsoluble-epoxide-hydrolasesEH-inhibitoromega-3-fatty-acidsDHA-metabolitesEDPsanti-angiogenictumor-growthmetastasispain-researchinflammatory-diseasediabetic-neuropathycancer-therapychemotherapy-side-effectsdebris-stimulated-metastasiscytokine-stormmacrophageinflammation-resolutioneicosanoid-pathwayprostaglandin-receptorEP4-antagonistclinical-trialsEicOsisacademic-industry-collaborationtranslational-researchfundamental-scienceinsect-metamorphosiscaterpillarbutterflygreen-insecticideblood-pressurefibrosisimmunitytissue-growthchronic-painnon-opiate-analgesiccompanion-animalhuman-healthdistinguished-professorNational-Academy-of-SciencesNational-Academy-of-InventorsUC-DavisSuperfund-ProgramNIHNIEHSRIVER-programbiotechnology-trainingpeer-reviewed-publicationslipidomicsfatty-acid-diolshigh-fat-dietknockout-mousepharmacological-inhibitionmolecular-analysessignaling-pathwaymechanistic-studiesUSDANational-Natural-Science-Foundation-of-Chinamass-spectrometrycompound-developmentPTUPBCOX-2-inhibitordual-inhibitorsurge-protectortumor-recurrencetreatment-resistanceovarian-cancerbreast-cancerpancreatic-cancerliver-cancercolon-cancerobesity-enhanced-cancerangiogenesismetastasis-preventiontumor-microenvironmentpositive-feedback-cycledormancy-escapesurgical-tumor-resectionperi-chemotherapeutic-managementdebris-clearancemacrophage-derived-stormpro-inflammatory-mediatorspro-angiogenic-mediatorslipid-autacoidcytokine-mediatorsresolution-mediatorsEETsnatural-pro-resolving-mediatorsholistic-modulationupstream-regulationdownstream-effectsnovel-therapeuticdrug-candidatePhase-I-clinical-trialPhase-II-clinical-trialhome-carecancer-centercomprehensive-cancer-centertransdisciplinary-researchsector-researchassistance-networkshared-protocolsorganizational-innovationpatient-centered-caremultidimensionalitypsychological-sufferingphysical-sufferingquality-of-lifetreatment-adherenceKarnofsky-performance-scorecomplete-blood-countblood-biochemistryblood-urea-nitrogenactivities-of-daily-livingindependenceprobioticsmulti-strain-probioticschemotherapy-related-side-effectsfatiguenauseaweaknessproneness-to-infectionsemerging-alternative-supplementspilot-trialopen-access-journalsedation-led-chemotherapyS.L.E.E.P.sleep-during-treatmentnight-administrationbed-allocationspecialized-nursinghome-visitseconomic-investmentfunding-prioritycardiovascular-diseasehealthcare-systemresearch-collaborationexcellence-centersscientific-contributionorganizational-ideascolleague-oncologistsfight-against-cancercurse-metaphorSleeping-Beauty-metaphorspinning-wheel-metaphorevil-witch-metaphorfairy-godmothers-metaphorpatient-narrativedoctor-patient-relationshipempathycare-extensionhospital-adaptationlife-derailmentdisease-integrationeveryday-lifenormalizationtolerance-improvementovercoming-chancespractical-limitationsresearch-ideaResearch-Ideas-and-OutcomesRIO-Journalfeature-storygraduate-studentUC-BerkeleySarjeet-GillUC-Riverside50-years-research900-peer-reviewed-papers17,000-peer-reviewed-papersenzyme-importance-recognitionmammalian-biologyregulatory-moleculesdegradation-controlbiosynthesis-controlepoxy-fatty-acid-chemical-mediatorsblood-pressure-controlfibrosis-controlimmunity-controltissue-growth-controlpain-controlinflammation-controlnon-addictive-drugorally-activeseed-fund-grantsNIH/NINDS-Blueprint-Development-Granthuman-clinical-trials2019-scheduleWilliam-Schmidtvice-president-clinical-developmentlarge-NIH-grantdiabetic-neuropathic-painJun-Yan-Liuhuman-sample-collectionWeicang-WangJianan-ZhangJun-YangJia-SunSung-Hee-HwangDebin-WanYuxin-WangWiepeng-QiHaixia-YangYeonhwa-ParkKatherine-SanidadDaeyoung-KimZhang-labUniversity-of-Massachusettsassistant-professor-food-sciencecolonic-inflammation-preventioninflammatory-bowel-disease-preventioncolon-cancer-prevention30-percent-Americans-obese30-60-percent-higher-colon-cancer-riskthird-most-common-cancersecond-leading-cause-cancer-deathmechanisms-not-well-understoodfew-effective-strategiessEH-over-expression-obese-micepharmacological-inhibition-abolishes-obesity-induced-inflammationgenetic-deletion-abolishes-obesity-induced-inflammationactivation-pro-tumorigenic-pathwaysessential-enzymenovel-agentsWnt-pathway90-percent-sporadic-colorectal-cancersactivating-mutationsobesity-increases-Wnt-activationabolished-by-inhibitors-and-knockoutblocked-obesity-induced-colon-inflammationmeticulous-jobbiologically-active-fatsblocking-diol-production-blocks-inflammationlipidomics-techniqueconsistent-resultssignaling-pathway-mechanistic-studiespotential-treatmenthuman-clinical-trials-this-yearUSDA-National-Institute-Food-AgricultureNIH-NIEHSNIEHS-Superfund-Research-ProgramNational-Natural-Science-Foundation-ChinaZuodong-Zhangpostdoctoral-researcher16-scientistsdietary-omega-3-fatty-acidsfish-oilstumor-growth-reductioncancer-spread-reduction580,000-Americans-die-annuallycytochrome-P450-epoxygenase-metabolitesDHAepoxy-docosapentaenoic-acidsblood-supply-blockadetumor-inhibitionmetastasis-inhibitionnatural-EDP-stabilizationsoluble-epoxide-hydrolase-inhibitorpain-control-developmenthypertension-control-developmenthuman-studies-cancer-risk-reductionmechanism-poorly-understoodnovel-mechanism-provisionpotent-anti-cancer-effectspotent-anti-metastatic-effectscurrent-anti-cancer-drugsangiogenesis-blockadehypertension-side-effectsnew-mechanism-angiogenesis-blockadeblood-vessel-wideningreduced-side-effectsmice-studiessorafenib-combinationefficacy-improvementside-effect-reductionfood-science-doctorateUniversity-of-Wisconsin-MadisonLisa-MahakianKatherine-FerraraXiaowen-Hupromise-demonstrationepoxides-DHA-strongly-anti-angiogenicepoxides-ARA-mildly-angiogenictumor-encouragementwound-healing-encouragementopposite-effects-background-lipidshumans-as-mice-assumptionhigh-omega-3-low-omega-6-backgroundsorafenib-regorafenib-potentiationCharles-SerhanHarvard-Medical-Schoolomega-3-autacoid-expertSimon-Gelman-ProfessorAnesthesia-Perioperative-Pain-Medicinefull-appreciation-stepbioactive-products-DHA-metabolomemetabolic-conversion-pivotalvascular-mechanismscancer-biologyvascular-biologytranslation-to-humansevidence-based-treatmentsJonathan-LindnerOregon-Health-Science-Universitycardiologistnew-drug-strategiesnutrition-knowledgediet-influence-susceptibilitytumor-progression-ratechemotherapy-responsereasonable-recommendationspathway-uncoveringtumor-development-influencetumor-growth-influencebeneficial-pathwayspreviously-unrecognized-anti-cancer-effectimportant-lipid-componentheart-disease-prevention-dietcancer-prevention-dietnew-blood-vessel-growth-suppressiontumor-blood-supply-shutdowndramatic-tumor-growth-slowingUC-Davis-Department-Entomology-websiteco-author-photosJianjun-DengHarvard-Medical-School-lead-author16-member-international-teamDipak-Panigrahy-laboratoriesBruce-Hammock-laboratoryinflammatory-response-controlchemotherapy-treatmentspancreatic-cancer-patientsliver-cancer-patientsdecades-old-drug-candidatebody's-raging-inflammatory-responsedeadly-inflammatory-responseProceedings-National-Academy-SciencesPNAS-publicationrodent-modelstwo-drug-combinationinflammation-reductiondebris-from-dying-tumor-cellsmetastasis-triggercancer-spreadsEH-enzyme-inhibitionEP4-prostaglandin-receptor-blockingeicosanoid-pathway-blockingcompound-synergypancreas-cancer-metastasis-preventionliver-cancer-metastasis-preventiondebris-clearance-stimulationINV-1120highly-potent-selective-EP4-antagonistPhase-I-clinical-trial-Texasmonotherapy-effectstrong-synergy-anti-PD-1sEH-candidate-synergygemcitabine-synergypreclinical-animal-modelsYongkui-SunIonova-Life-Science-chairmanbiotechnology-company-Chinabasic-biomedical-research-translationnovel-therapeuticsHammock-lab-co-lead-authorNational-Academy-EngineeringMerck-research-and-development-teamfruitful-academic-industry-collaborationexcessive-inflammationlipid-stormhuman-body-reactionpancreatic-cancer-therapydebris-increase-sEH-EP4-proteinspro-inflammatory-lipid-autacoidpro-angiogenic-lipid-autacoidinflammatory-response-control-importanceupstream-cytokine-modulationdownstream-cytokine-blockingholistic-eicosanoid-modulationinsidious-cancer-characteristicsdying-cells-immune-system-trainingtumor-microenvironment-favorabilitytherapy-combattingeffectiveness-renderingdouble-edged-sword-cancer-therapyinflammatory-immunosuppressive-injury-responsedormancy-escape-promotiontumor-recurrence-promotionVictoria-HaakUniversity-Buffalo-first-year-medical-studentChina-Agricultural-University-researchercompound-synthesisnovel-simple-effective-approachinflammation-turning-downcytokine-storm-preventiontumor-resection-consequencenatural-pro-resolving-mediator-concentration-increasebiological-system-actionpro-resolution-mediator-productioninflammation-modulationactive-resolution-processEicOsis-Human-Health-LLCUC-Davis-based-companyinhibitor-human-clinical-trialsTexas-trialsupstream-actioneicosanoid-down-regulationcytokine-storm-down-regulationpatient-help-optimismtremendous-clinic-translation-potentialPanigrahy-quote60,430-pancreatic-cancer-diagnoses-annually31,950-male28,480-female48,220-pancreatic-cancer-deaths-annually25,270-male22,950-female42,230-liver-cancer-diagnoses-annually29,890-male12,340-female30,230-liver-cancer-deaths-annually20,300-male9,930-femaleAmerican-Cancer-Society-statisticsliver-cancer-incidence-tripling-since-1980liver-cancer-death-rate-doublingchemotherapy-cancer-risk-elucidationmetastasis-prevention-promiserecurrence-prevention-promisesurgical-tumor-resection-followingpre-operative-inflammation-managementperi-chemotherapeutic-inflammation-managementcancer-recurrence-stav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• Lacunicambarus diogenes

  devil crayfish, devil crawfish

  Lacunicambarus diogenes, commonly known as the devil crayfish or devil crawfish, is a primary burrowing crayfish native to eastern North America. This species constructs and inhabits burrows in wet, muddy terrestrial habitats rather than living in permanent surface water. Its burrowing activities create refugia used by numerous other species, including documented use by eastern cicada killer wasps (Sphecius speciosus) as brooding habitat. The species ranges across the Atlantic Coastal Plain and Piedmont ecoregion from New Jersey to Georgia, with disjunct populations in Louisiana.

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