No-inference-from-higher-taxa

Guides

• Cancer borealis

  Jonah crab

  Cancer borealis, commonly known as the Jonah crab, is a marine brachyuran crab native to the western Atlantic Ocean. It inhabits waters from Newfoundland to Florida, primarily in rocky marine environments. The species possesses a rounded, rough-edged carapace with small light spots and robust claws with dark brown-black tips. Males reach larger sizes than females, with maximum carapace widths of 222 mm versus approximately 150 mm. The Jonah crab has been extensively studied as a model organism for neurophysiology, particularly for its stomatogastric nervous system, which has contributed to understanding neural circuit function and neuromuscular control.

  model-organismneurophysiologystomatogastric-ganglioncommercial-fisheryrocky-intertidalAtlantic-Oceandecapodcrustaceanion-channel-researchtemperature-adaptationpH-adaptationneural-circuitneuromuscularcompetitionfisheriesmarine-biologycell-identitytranscriptomicspotassium-channelsK2P-channelsmuscle-physiologystomatogastric-nervous-systembiogenic-amine-receptorsGABA-receptorsglutamate-receptorsacetylcholine-receptorsgap-junctionsinnexinsWnt-signalingobesity-researchcolon-cancer-researchsoluble-epoxide-hydrolasesEH-inhibitoromega-3-fatty-acidsDHA-metabolitesEDPsanti-angiogenictumor-growthmetastasispain-researchinflammatory-diseasediabetic-neuropathycancer-therapychemotherapy-side-effectsdebris-stimulated-metastasiscytokine-stormmacrophageinflammation-resolutioneicosanoid-pathwayprostaglandin-receptorEP4-antagonistclinical-trialsEicOsisacademic-industry-collaborationtranslational-researchfundamental-scienceinsect-metamorphosiscaterpillarbutterflygreen-insecticideblood-pressurefibrosisimmunitytissue-growthchronic-painnon-opiate-analgesiccompanion-animalhuman-healthdistinguished-professorNational-Academy-of-SciencesNational-Academy-of-InventorsUC-DavisSuperfund-ProgramNIHNIEHSRIVER-programbiotechnology-trainingpeer-reviewed-publicationslipidomicsfatty-acid-diolshigh-fat-dietknockout-mousepharmacological-inhibitionmolecular-analysessignaling-pathwaymechanistic-studiesUSDANational-Natural-Science-Foundation-of-Chinamass-spectrometrycompound-developmentPTUPBCOX-2-inhibitordual-inhibitorsurge-protectortumor-recurrencetreatment-resistanceovarian-cancerbreast-cancerpancreatic-cancerliver-cancercolon-cancerobesity-enhanced-cancerangiogenesismetastasis-preventiontumor-microenvironmentpositive-feedback-cycledormancy-escapesurgical-tumor-resectionperi-chemotherapeutic-managementdebris-clearancemacrophage-derived-stormpro-inflammatory-mediatorspro-angiogenic-mediatorslipid-autacoidcytokine-mediatorsresolution-mediatorsEETsnatural-pro-resolving-mediatorsholistic-modulationupstream-regulationdownstream-effectsnovel-therapeuticdrug-candidatePhase-I-clinical-trialPhase-II-clinical-trialhome-carecancer-centercomprehensive-cancer-centertransdisciplinary-researchsector-researchassistance-networkshared-protocolsorganizational-innovationpatient-centered-caremultidimensionalitypsychological-sufferingphysical-sufferingquality-of-lifetreatment-adherenceKarnofsky-performance-scorecomplete-blood-countblood-biochemistryblood-urea-nitrogenactivities-of-daily-livingindependenceprobioticsmulti-strain-probioticschemotherapy-related-side-effectsfatiguenauseaweaknessproneness-to-infectionsemerging-alternative-supplementspilot-trialopen-access-journalsedation-led-chemotherapyS.L.E.E.P.sleep-during-treatmentnight-administrationbed-allocationspecialized-nursinghome-visitseconomic-investmentfunding-prioritycardiovascular-diseasehealthcare-systemresearch-collaborationexcellence-centersscientific-contributionorganizational-ideascolleague-oncologistsfight-against-cancercurse-metaphorSleeping-Beauty-metaphorspinning-wheel-metaphorevil-witch-metaphorfairy-godmothers-metaphorpatient-narrativedoctor-patient-relationshipempathycare-extensionhospital-adaptationlife-derailmentdisease-integrationeveryday-lifenormalizationtolerance-improvementovercoming-chancespractical-limitationsresearch-ideaResearch-Ideas-and-OutcomesRIO-Journalfeature-storygraduate-studentUC-BerkeleySarjeet-GillUC-Riverside50-years-research900-peer-reviewed-papers17,000-peer-reviewed-papersenzyme-importance-recognitionmammalian-biologyregulatory-moleculesdegradation-controlbiosynthesis-controlepoxy-fatty-acid-chemical-mediatorsblood-pressure-controlfibrosis-controlimmunity-controltissue-growth-controlpain-controlinflammation-controlnon-addictive-drugorally-activeseed-fund-grantsNIH/NINDS-Blueprint-Development-Granthuman-clinical-trials2019-scheduleWilliam-Schmidtvice-president-clinical-developmentlarge-NIH-grantdiabetic-neuropathic-painJun-Yan-Liuhuman-sample-collectionWeicang-WangJianan-ZhangJun-YangJia-SunSung-Hee-HwangDebin-WanYuxin-WangWiepeng-QiHaixia-YangYeonhwa-ParkKatherine-SanidadDaeyoung-KimZhang-labUniversity-of-Massachusettsassistant-professor-food-sciencecolonic-inflammation-preventioninflammatory-bowel-disease-preventioncolon-cancer-prevention30-percent-Americans-obese30-60-percent-higher-colon-cancer-riskthird-most-common-cancersecond-leading-cause-cancer-deathmechanisms-not-well-understoodfew-effective-strategiessEH-over-expression-obese-micepharmacological-inhibition-abolishes-obesity-induced-inflammationgenetic-deletion-abolishes-obesity-induced-inflammationactivation-pro-tumorigenic-pathwaysessential-enzymenovel-agentsWnt-pathway90-percent-sporadic-colorectal-cancersactivating-mutationsobesity-increases-Wnt-activationabolished-by-inhibitors-and-knockoutblocked-obesity-induced-colon-inflammationmeticulous-jobbiologically-active-fatsblocking-diol-production-blocks-inflammationlipidomics-techniqueconsistent-resultssignaling-pathway-mechanistic-studiespotential-treatmenthuman-clinical-trials-this-yearUSDA-National-Institute-Food-AgricultureNIH-NIEHSNIEHS-Superfund-Research-ProgramNational-Natural-Science-Foundation-ChinaZuodong-Zhangpostdoctoral-researcher16-scientistsdietary-omega-3-fatty-acidsfish-oilstumor-growth-reductioncancer-spread-reduction580,000-Americans-die-annuallycytochrome-P450-epoxygenase-metabolitesDHAepoxy-docosapentaenoic-acidsblood-supply-blockadetumor-inhibitionmetastasis-inhibitionnatural-EDP-stabilizationsoluble-epoxide-hydrolase-inhibitorpain-control-developmenthypertension-control-developmenthuman-studies-cancer-risk-reductionmechanism-poorly-understoodnovel-mechanism-provisionpotent-anti-cancer-effectspotent-anti-metastatic-effectscurrent-anti-cancer-drugsangiogenesis-blockadehypertension-side-effectsnew-mechanism-angiogenesis-blockadeblood-vessel-wideningreduced-side-effectsmice-studiessorafenib-combinationefficacy-improvementside-effect-reductionfood-science-doctorateUniversity-of-Wisconsin-MadisonLisa-MahakianKatherine-FerraraXiaowen-Hupromise-demonstrationepoxides-DHA-strongly-anti-angiogenicepoxides-ARA-mildly-angiogenictumor-encouragementwound-healing-encouragementopposite-effects-background-lipidshumans-as-mice-assumptionhigh-omega-3-low-omega-6-backgroundsorafenib-regorafenib-potentiationCharles-SerhanHarvard-Medical-Schoolomega-3-autacoid-expertSimon-Gelman-ProfessorAnesthesia-Perioperative-Pain-Medicinefull-appreciation-stepbioactive-products-DHA-metabolomemetabolic-conversion-pivotalvascular-mechanismscancer-biologyvascular-biologytranslation-to-humansevidence-based-treatmentsJonathan-LindnerOregon-Health-Science-Universitycardiologistnew-drug-strategiesnutrition-knowledgediet-influence-susceptibilitytumor-progression-ratechemotherapy-responsereasonable-recommendationspathway-uncoveringtumor-development-influencetumor-growth-influencebeneficial-pathwayspreviously-unrecognized-anti-cancer-effectimportant-lipid-componentheart-disease-prevention-dietcancer-prevention-dietnew-blood-vessel-growth-suppressiontumor-blood-supply-shutdowndramatic-tumor-growth-slowingUC-Davis-Department-Entomology-websiteco-author-photosJianjun-DengHarvard-Medical-School-lead-author16-member-international-teamDipak-Panigrahy-laboratoriesBruce-Hammock-laboratoryinflammatory-response-controlchemotherapy-treatmentspancreatic-cancer-patientsliver-cancer-patientsdecades-old-drug-candidatebody's-raging-inflammatory-responsedeadly-inflammatory-responseProceedings-National-Academy-SciencesPNAS-publicationrodent-modelstwo-drug-combinationinflammation-reductiondebris-from-dying-tumor-cellsmetastasis-triggercancer-spreadsEH-enzyme-inhibitionEP4-prostaglandin-receptor-blockingeicosanoid-pathway-blockingcompound-synergypancreas-cancer-metastasis-preventionliver-cancer-metastasis-preventiondebris-clearance-stimulationINV-1120highly-potent-selective-EP4-antagonistPhase-I-clinical-trial-Texasmonotherapy-effectstrong-synergy-anti-PD-1sEH-candidate-synergygemcitabine-synergypreclinical-animal-modelsYongkui-SunIonova-Life-Science-chairmanbiotechnology-company-Chinabasic-biomedical-research-translationnovel-therapeuticsHammock-lab-co-lead-authorNational-Academy-EngineeringMerck-research-and-development-teamfruitful-academic-industry-collaborationexcessive-inflammationlipid-stormhuman-body-reactionpancreatic-cancer-therapydebris-increase-sEH-EP4-proteinspro-inflammatory-lipid-autacoidpro-angiogenic-lipid-autacoidinflammatory-response-control-importanceupstream-cytokine-modulationdownstream-cytokine-blockingholistic-eicosanoid-modulationinsidious-cancer-characteristicsdying-cells-immune-system-trainingtumor-microenvironment-favorabilitytherapy-combattingeffectiveness-renderingdouble-edged-sword-cancer-therapyinflammatory-immunosuppressive-injury-responsedormancy-escape-promotiontumor-recurrence-promotionVictoria-HaakUniversity-Buffalo-first-year-medical-studentChina-Agricultural-University-researchercompound-synthesisnovel-simple-effective-approachinflammation-turning-downcytokine-storm-preventiontumor-resection-consequencenatural-pro-resolving-mediator-concentration-increasebiological-system-actionpro-resolution-mediator-productioninflammation-modulationactive-resolution-processEicOsis-Human-Health-LLCUC-Davis-based-companyinhibitor-human-clinical-trialsTexas-trialsupstream-actioneicosanoid-down-regulationcytokine-storm-down-regulationpatient-help-optimismtremendous-clinic-translation-potentialPanigrahy-quote60,430-pancreatic-cancer-diagnoses-annually31,950-male28,480-female48,220-pancreatic-cancer-deaths-annually25,270-male22,950-female42,230-liver-cancer-diagnoses-annually29,890-male12,340-female30,230-liver-cancer-deaths-annually20,300-male9,930-femaleAmerican-Cancer-Society-statisticsliver-cancer-incidence-tripling-since-1980liver-cancer-death-rate-doublingchemotherapy-cancer-risk-elucidationmetastasis-prevention-promiserecurrence-prevention-promisesurgical-tumor-resection-followingpre-operative-inflammation-managementperi-chemotherapeutic-inflammation-managementcancer-recurrence-stav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• Phidippus cardinalis

  cardinal jumper

  Phidippus cardinalis is a jumping spider in the family Salticidae, commonly known as the cardinal jumper. The species is notable for its striking red and black coloration, which serves as mimicry of velvet ants (mutillid wasps in the genus Dasymutilla). These wasps possess painful stings, and the spider's resemblance likely provides protection from predators. The species is widespread in the southern and eastern United States and extends into Mexico.

  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