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Cancer borealis
Jonah crab
Cancer borealis, commonly known as the Jonah crab, is a marine brachyuran crab native to the western Atlantic Ocean. It inhabits waters from Newfoundland to Florida, primarily in rocky marine environments. The species possesses a rounded, rough-edged carapace with small light spots and robust claws with dark brown-black tips. Males reach larger sizes than females, with maximum carapace widths of 222 mm versus approximately 150 mm. The Jonah crab has been extensively studied as a model organism for neurophysiology, particularly for its stomatogastric nervous system, which has contributed to understanding neural circuit function and neuromuscular control.
model-organism neurophysiology stomatogastric-ganglion commercial-fishery rocky-intertidal Atlantic-Ocean decapod crustacean ion-channel-research temperature-adaptation pH-adaptation neural-circuit neuromuscular competition fisheries marine-biology cell-identity transcriptomics potassium-channels K2P-channels muscle-physiology stomatogastric-nervous-system biogenic-amine-receptors GABA-receptors glutamate-receptors acetylcholine-receptors gap-junctions innexins Wnt-signaling obesity-research colon-cancer-research soluble-epoxide-hydrolase sEH-inhibitor omega-3-fatty-acids DHA-metabolites EDPs anti-angiogenic tumor-growth metastasis pain-research inflammatory-disease diabetic-neuropathy cancer-therapy chemotherapy-side-effects debris-stimulated-metastasis cytokine-storm macrophage inflammation-resolution eicosanoid-pathway prostaglandin-receptor EP4-antagonist clinical-trials EicOsis academic-industry-collaboration translational-research fundamental-science insect-metamorphosis caterpillar butterfly green-insecticide blood-pressure fibrosis immunity tissue-growth chronic-pain non-opiate-analgesic companion-animal human-health distinguished-professor National-Academy-of-Sciences National-Academy-of-Inventors UC-Davis Superfund-Program NIH NIEHS RIVER-program biotechnology-training peer-reviewed-publications lipidomics fatty-acid-diols high-fat-diet knockout-mouse pharmacological-inhibition molecular-analyses signaling-pathway mechanistic-studies USDA National-Natural-Science-Foundation-of-China mass-spectrometry compound-development PTUPB COX-2-inhibitor dual-inhibitor surge-protector tumor-recurrence treatment-resistance ovarian-cancer breast-cancer pancreatic-cancer liver-cancer colon-cancer obesity-enhanced-cancer angiogenesis metastasis-prevention tumor-microenvironment positive-feedback-cycle dormancy-escape surgical-tumor-resection peri-chemotherapeutic-management debris-clearance macrophage-derived-storm pro-inflammatory-mediators pro-angiogenic-mediators lipid-autacoid cytokine-mediators resolution-mediators EETs natural-pro-resolving-mediators holistic-modulation upstream-regulation downstream-effects novel-therapeutic drug-candidate Phase-I-clinical-trial Phase-II-clinical-trial home-care cancer-center comprehensive-cancer-center transdisciplinary-research sector-research assistance-network shared-protocols organizational-innovation patient-centered-care multidimensionality psychological-suffering physical-suffering quality-of-life treatment-adherence Karnofsky-performance-score complete-blood-count blood-biochemistry blood-urea-nitrogen activities-of-daily-living independence probiotics multi-strain-probiotics chemotherapy-related-side-effects fatigue nausea weakness proneness-to-infections emerging-alternative-supplements pilot-trial open-access-journal sedation-led-chemotherapy S.L.E.E.P.sleep-during-treatment night-administration bed-allocation specialized-nursing home-visits economic-investment funding-priority cardiovascular-disease healthcare-system research-collaboration excellence-centers scientific-contribution organizational-ideas colleague-oncologists fight-against-cancer curse-metaphor Sleeping-Beauty-metaphor spinning-wheel-metaphor evil-witch-metaphor fairy-godmothers-metaphor patient-narrative doctor-patient-relationship empathy care-extension hospital-adaptation life-derailment disease-integration everyday-life normalization tolerance-improvement overcoming-chances practical-limitations research-idea Research-Ideas-and-Outcomes RIO-Journal feature-story graduate-student UC-Berkeley Sarjeet-Gill UC-Riverside 50-years-research 900-peer-reviewed-papers 17,000-peer-reviewed-papers enzyme-importance-recognition mammalian-biology regulatory-molecules degradation-control biosynthesis-control epoxy-fatty-acid-chemical-mediators blood-pressure-control fibrosis-control immunity-control tissue-growth-control pain-control inflammation-control non-addictive-drug orally-active seed-fund-grants NIH/NINDS-Blueprint-Development-Grant human-clinical-trials 2019-schedule William-Schmidt vice-president-clinical-development large-NIH-grant diabetic-neuropathic-pain Jun-Yan-Liu human-sample-collection Weicang-Wang Jianan-Zhang Jun-Yang Jia-Sun Sung-Hee-Hwang Debin-Wan Yuxin-Wang Wiepeng-Qi Haixia-Yang Yeonhwa-Park Katherine-Sanidad Daeyoung-Kim Zhang-lab University-of-Massachusetts assistant-professor-food-science colonic-inflammation-prevention inflammatory-bowel-disease-prevention colon-cancer-prevention 30-percent-Americans-obese 30-60-percent-higher-colon-cancer-risk third-most-common-cancer second-leading-cause-cancer-death mechanisms-not-well-understood few-effective-strategies sEH-over-expression-obese-mice pharmacological-inhibition-abolishes-obesity-induced-inflammation genetic-deletion-abolishes-obesity-induced-inflammation activation-pro-tumorigenic-pathways essential-enzyme novel-agents Wnt-pathway 90-percent-sporadic-colorectal-cancers 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