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Manduca sexta
Carolina sphinx moth, tobacco hawk moth, tobacco hornworm, Goliath worm
Manduca sexta is a large sphinx moth native to the Americas, widely recognized as both a significant agricultural pest and a premier model organism in biological research. The species exhibits marked sexual dimorphism in adults and undergoes complete metamorphosis through five larval instars. Larvae are notable for their ability to sequester and metabolize nicotine from tobacco plants, using it as a chemical defense against predators. The species has been extensively studied in neurobiology, developmental biology, and immunology due to its large size, short life cycle, and accessible nervous system.