Lock and Key Hypothesis

Definition

A model proposed by Emil Fischer in the early 20th century to explain enzyme-substrate interactions. It suggests that enzymes have a specific active site that fits a particular substrate molecule like a lock and key.

Etymology

Named after the analogy of a lock and key, proposed by Emil Fischer.

Example

The lock and key hypothesis explains how enzymes can be highly specific in their reactions.

Related Terms

• Enzyme
• Substrate
• Active site